VONVENDI is used in adults (age 18 years and older) diagnosed with von Willebrand disease to: 1) treat and control bleeding episodes; 2) prevent excessive bleeding during and after surgery

Manufactured without human blood or plasma.VONVENDI is recombinant, meaning it's made without using human blood. This technology avoids the risk of spreading diseases through infected human blood. Can be used with or without recombinant FVIII as directed.Depending on your specific situation, your healthcare provider will decide if you may use VONVENDI by itself, or if you require additional recombinant FVIII (rFVIII).

VONVENDI is infused into your blood stream, where it acts like your body's natural von Willebrand factor (VWF), helping to form clots, and helping your own FVIII to work. At the site of injury, VONVENDI works to help stick blood proteins called platelets to the wall of the damaged blood vessel, forming a clot.

What is VONVENDI®[von Willebrand factor (Recombinant)]&?

Approved for two separate uses

Your healthcare provider may prescribe VONVENDI for two different uses: on-demand treatment of bleeds and to prevent excessive bleeding during and after surgery.¹

On-demand

VONVENDI can be used on-demand by adults with VWD to control major and minor bleeds in all locations, including mouth bleeds, nosebleeds, heavy menstrual bleeds, GI bleeds, and joint bleeds.¹

Learn about using VONVENDI on-demand

For surgery

VONVENDI can be used to prevent excessive bleeding during and after surgical procedures, such as tooth extractions and colonoscopies.¹

Learn about VONVENDI for surgery

See Detailed Important Risk Information

What is VONVENDI?

VONVENDI is used in adults (age 18 years and older) diagnosed with von Willebrand disease to:

treat and control bleeding episodes
prevent excessive bleeding during and after surgery

Who should not use VONVENDI?

You should not use VONVENDI if you:

Are allergic to any ingredients in VONVENDI
Are allergic to mice or hamsters

VONVENDI^® [von Willebrand factor (recombinant)] Important Information

What is VONVENDI?

VONVENDI is used in adults (age 18 years and older) diagnosed with von Willebrand disease to:

treat and control bleeding episodes
prevent excessive bleeding during and after surgery

Detailed Important Risk Information

Who should not use VONVENDI?

You should not use VONVENDI if you:

Are allergic to any ingredients in VONVENDI.
Are allergic to mice or hamsters.

Tell your healthcare provider if you are pregnant or breastfeeding because VONVENDI may not be right for you.

How should I use VONVENDI?

Your first dose of VONVENDI for each bleeding episode may be administered with a recombinant factor VIII as instructed by your healthcare provider.

Your healthcare provider will instruct you whether additional doses of VONVENDI with or without recombinant factor VIII are needed.

What should I tell my healthcare provider before I use VONVENDI?

You should tell your healthcare provider if you:

Have or have had any medical problems.
Take any medicines, including prescription and non-prescription medicines, such as over-the-counter medicines, supplements or herbal remedies.
Have any allergies, including allergies to mice or hamsters.
Are breastfeeding. It is not known if VONVENDI passes into your milk and if it can harm your baby.
Are pregnant or planning to become pregnant. It is not known if VONVENDI can harm your unborn baby.
Have been told that you have inhibitors to von Willebrand factor (because VONVENDI may not work for you).
Have been told that you have inhibitors to blood coagulation factor VIII.

What else should I know about VONVENDI and von Willebrand Disease?

Your body can form inhibitors to von Willebrand factor or factor VIII. An inhibitor is part of the body's normal defense system. If you form inhibitors, it may stop VONVENDI or factor VIII from working properly. Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to von Willebrand factor or factor VIII.

What are the possible side effects of VONVENDI?

You can have an allergic reaction to VONVENDI.

Call your healthcare provider right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting.

Side effects that have been reported with VONVENDI include: nausea, vomiting, tingling or burning at infusion site, chest discomfort, dizziness, hot flashes, itching, high blood pressure, muscle twitching, unusual taste, blood clots and increased heart rate.

Tell your healthcare provider about any side effects that bother you or do not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see VONVENDI full Prescribing Information

What is Vonvendi^®?

Created specifically for von Willebrand disease (VWD) bleeding episodes¹

Key facts about VONVENDI

Manufactured without human blood or plasma

Can be used with or without recombinant FVIII as directed

Approved for two separate uses

On-demand

For surgery

How VONVENDI works

VONVENDI^® side effects

References

What is Vonvendi®?

Created specifically for von Willebrand disease (VWD) bleeding episodes1

Key facts about VONVENDI

Manufactured without human blood or plasma

Can be used with or without recombinant FVIII as directed

Approved for two separate uses

On-demand

For surgery

How VONVENDI works

VONVENDI® side effects

References

What is Vonvendi^®?

Created specifically for von Willebrand disease (VWD) bleeding episodes¹

VONVENDI^® side effects