What is Vonvendi®?
Created specifically for von Willebrand disease (VWD) bleeding episodes
VONVENDI is the first and only recombinant von Willebrand factor (rVWF) treatment that's approved for on-demand and surgery for adults and children. It's also approved to help reduce the number of bleeding episodes when used regularly (prophylaxis) in adults with all types of VWD, including those previously treated on-demand or who used a pdVWF product for prophylaxis.
Key facts about VONVENDI
Uniquely long half-life
VONVENDI has a uniquely long half-life in children and adults. Half-life describes how long it takes for the body to eliminate half of the dose of a product. For example, if the half-life of a product is 22 hours, then 22 hours after dosing, approximately 50% of the dose remains in your body.
VONVENDI has a half-life of 22.6 hours in adults and 14.0 hours in children.*†
Manufactured without human blood or plasma
VONVENDI is recombinant, meaning it's made without using human blood. This technology avoids the risk of spreading diseases through infected human blood.
Can be used with or without recombinant FVIII as directed
Not every bleed requires additional FVIII. Depending on your specific situation, your healthcare provider will decide if you may use VONVENDI by itself, or if you require additional recombinant FVIII (rFVIII).
*The pharmacokinetic (PK) profile of VONVENDI in adults was determined based on data analyses from 2 clinical trials. Subjects were evaluated in the non-bleeding state.
†The pharmacokinetics of pediatric patients were estimated based on sparse PK (blood) samples collected during a pediatric clinical trial. This PK assessment was following a single-dose (50 IU/kg) infusion of VONVENDI.
IU=international unit; PK=pharmacokinetics, which helps determine how quickly or slowly a treatment breaks down in the body; SD=standard deviation, which is a measure of how much a group of numbers vary from the average; VWF:RCo=von Willebrand factor (VWF) ristocetin cofactor.
VONVENDI alone enables a sustained rise in FVIII levels
This chart shows the average VWF and FVIII levels of 16 adult patients with severe VWD after they received a single infusion of VONVENDI while not bleeding. Before VONVENDI was given, these patients had low levels of VWF and FVIII.
*Analyses were performed in both the adult on-demand and surgery trials in a non-bleeding state. Data shown on the graph correspond to the on-demand trial, with adult patients receiving a dose of 50 IU/kg.
FVIII=factor VIII; PK=pharmacokinetics.
Approved for 3 different uses
Your healthcare provider may prescribe VONVENDI for 3 different uses: on-demand treatment and control of bleeds, to prevent excessive bleeding during and after surgery, and to reduce the number of bleeding episodes for adults when used regularly (prophylaxis).
Prophylaxis
VONVENDI can be used on a routine basis to reduce the frequency of bleeding episodes in adults with all types of VWD.
On-demand
VONVENDI can be used on-demand by adults and children with VWD to control both major and minor bleeds including mouth bleeds, nosebleeds, heavy menstrual bleeds, and joint bleeds.
For surgery
VONVENDI can be used to prevent excessive bleeding for adults and children during and after surgical procedures.
Approved uses for children
VONVENDI is also the first and only recombinant therapy approved to treat both on-demand and surgical bleeds in children. Explore how it could help control your child’s bleeds.
How VONVENDI works
VONVENDI is infused into your bloodstream, where it acts like your body's natural von Willebrand factor (VWF), helping to form clots, and helping your own FVIII to work.
Only VONVENDI can provide functional VWF without adding extra FVIII to the bloodstream upon infusion. VONVENDI contains trace amounts of FVIII.
VONVENDI side effects
Always talk to your healthcare provider before taking any prescription medication, including VONVENDI. Learn more about VONVENDI side effects and safety.
Try for free
You may be eligible to try VONVENDI for free with our FREEDOM OF CHOICE™ program.
Get personalized support
Community Education Specialists can help answer your questions about VONVENDI.