What is Vonvendi®?

Created specifically for von Willebrand disease (VWD) bleeding episodes1

VONVENDI is the first and only recombinant von Willebrand factor (rVWF) treatment approved for on-demand and surgery for adults with all types of VWD (Type 1, Type 2, and Type 3).1,2 It helps reduce the number of bleeding episodes and is the only treatment approved for prophylaxis in adults with severe Type 3 VWD receiving on-demand therapy.1

VONVENDI® container and glass bottles.

Key facts about VONVENDI

Four blood cells in a circle with a slash to show VWD factor treatment is manufactured without human blood or plasma.

Manufactured without human blood or plasma

VONVENDI is recombinant, meaning it's made without using human blood. This technology avoids the risk of spreading diseases through infected human blood.3

A prescription bottle indicating VONVENDI® can be used with or without recombinant FVIII as directed.

Can be used with or without recombinant FVIII as directed

Depending on your specific situation, your healthcare provider will decide if you may use VONVENDI by itself, or if you require additional recombinant FVIII (rFVIII).1

Approved for three different uses

Your healthcare provider may prescribe VONVENDI for three different uses: on-demand treatment of bleeds, to prevent excessive bleeding during and after surgery, and to reduce the number of bleeding episodes when used regularly (prophylaxis).1

On-demand prophylaxis icon.


VONVENDI can be used on a routine to reduce the number of bleeds (prophylaxis) in adults with severe Type 3 VWD receiving on-demand therapy1

Learn about VONVENDI for prophylaxis
Bleeding finger icon.


VONVENDI can be used on-demand by adults with VWD to control major and minor bleeds in all locations, including mouth bleeds, nosebleeds, heavy menstrual bleeds, GI bleeds, and joint bleeds.1

Learn about using VONVENDI on-demand
Doctor performing surgery on a patient icon.

For surgery

VONVENDI can be used to prevent excessive bleeding during and after surgical procedures, such as tooth extractions and colonoscopies.1

Learn about VONVENDI for surgery

How VONVENDI works

VONVENDI is infused into your blood stream, where it acts like your body's natural von Willebrand factor (VWF), helping to form clots, and helping your own FVIII to work.1

White and red blood cells.
Doctor talking to her VWD patient.

VONVENDI® side effects

Always talk to your healthcare provider before taking any prescription medication, including VONVENDI. Learn more about VONVENDI side effects and safety.

See safety info
Woman handwriting notes in her journal.
Use as prophylaxis

In certain adult patients with severe Type 3 VWD, VONVENDI is approved to reduce the frequency of bleeding episodes.1

Learn more
Real VWD patient, Erica standing next to some flowers and smiling. VONVENDI® can be used for on-demand use.
Use on demand

In adult patients with VWD, VONVENDI is approved to control bleeds as they occur.1

Learn more


  1. VONVENDI Prescribing Information
  2. Baxalta receives FDA Approval for VONVENDI, the first and only recombinant treatment for adults affected by von Willebrand disease. Business Wire. December 8, 2015. Accessed July 9, 2020. https://www.businesswire.com/news/home/20151208006689/en/Baxalta-Receives-FDA-Approval-VONVENDIRecombinant-Treatment
  3. Franchini M, Mannucci PM. Von Willebrand factor (Vonvendi®): the first recombinant product licensed for the treatment of von Willebrand disease. Expert Rev Hematol. 2016;9(9):825-830.