VONVENDI® and surgery

VONVENDI was tested in a clinical trial for surgeries and procedures.1

Doctor showing some facts about VONVENDI® with her patient.

Trial design

VONVENDI was studied in 15 adults with all types of severe von Willebrand disease (VWD) to test how it would work to prevent excessive bleeding during and after surgery. VONVENDI was first given 12-24 hours before surgery to give time for each person's natural factor VIII (FVIII) to rise. VONVENDI was given again within 1 hour before surgery, either with or without recombinant FVIII (rFVIII), based on level of FVIII. For up to 72 hours after surgery, VONVENDI was dosed with or without rFVIII every 12-48 hours as needed to prevent excessive bleeding. Study investigators rated bleeding control as "Excellent," "Good," "Moderate," or "None," with success defined as "Excellent" or "Good."1,2

Ribbon pin icon showing 100% of VONVENDI® surgical patients (15/15) were managed successfully.

100% of surgical patients (15/15) were managed successfully, with 9/15 rated as "Excellent" and 6/15 rated as "good"1

Blood cells icon.

The amount of blood loss experienced by people in the study was comparable to that of a person without VWD1

Number one icon.

Most people (10/15) needed only VONVENDI to manage their surgical bleeding2

Bleed control for a range of procedures

VONVENDI can be used to prevent excessive bleeding during and after major and minor surgeries and procedures in various locations, including1:

Mouth icon.


(eg, dental extraction)
Nose icon.


(eg, nasopharyngoscopy)
Uterus icon.

Female reproductive system

(eg, cyst removal)
Colon icon.

GI tract

(eg, colonoscopy)
Joints icon.


(eg, joint replacement)

Ready to talk to your healthcare provider?

Our easy-to-use Discussion Guide, used alongside our bleed tracker, can help you speak to your healthcare provider about finding a treatment that's right for you.

Download the guide
von Willebrand disease discussion guide.
Leslie, Real VWD patient smiling.

Leslie's story

Diagnosed with VWD in 2003

"Once I was trained on how to do my own infusion, I infused on the eve of the surgery and again right before. I also infused after surgery—this was my normal for any surgery. I was amazed at how well this treatment worked for me."

"I try not to let my blood disorder get me down. As I tell my son, life is what you make of it. My adventure is not done; my story is not finished."

See her story
Erica, Real VWD patient smiling.

Erica's story

Diagnosed with VWD in 1981

"I feel fortunate that there's been an increase in awareness when it comes to VWD, from diagnosis and available information to patient care."

"The doctor came back with a diagnosis: VWD type 2B. It was something I had never heard of before… but something that would change my life forever."

See her story
Nicole, Real VWD patient smiling.

Nicole's story

Diagnosed with VWD in 2009

"Although I've faced many battles since I was diagnosed, the amount of support I had from all the other patients fighting the same battle gave me strength."

"I was experiencing nosebleeds that lasted 15 minutes or more almost every day. My new doctor told me I needed to manage my bleeds, and discussed beginning a treatment called VONVENDI."

See her story
Real VWD patient, Erica standing next to some flowers and smiling. VONVENDI® can be used for on-demand treatment.
Use on-demand

In adult patients with VWD, VONVENDI is approved to control bleeds as they occur.1

Learn more
Doctor going over documents with her patient.

See the most common side effects.

Learn more


  1. VONVENDI Prescribing Information
  2. Peyvandi F, Mamaev A, Wang JD, et al. Phase 3 study of recombinant von Willebrand factor in patients with severe von Willebrand disease who are undergoing elective surgery. J Thromb Haemost. 2019;17(1):52-62.