Side effects that have been reported with VONVENDI include: headache, nausea, vomiting, tingling or burning at infusion site, chest discomfort, dizziness, joint pain, joint injury, increased liver enzyme level in blood, hot flashes, itching, high blood pressure, muscle twitching, unusual taste, blood clots and increased heart rate. Tell your healthcare provider about any side effects that bother you or do not go away.1
Four studies were conducted in subjects with von Willebrand disease and one was conducted in subjects with hemophilia A. The adverse reactions listed below are from three VWD clinical trials with a total of 80 participants, during which VONVENDI was used for pharmacokinetics assessment, on-demand treatment, and management of bleeding episodes in patients undergoing surgery.1
3.75% of participants (3 out of 80) experienced:
2.5% of participants (2 out of 80) experienced:
1.25% of participants (1 out of 80) experienced:
Of the 125 total adverse events observed during the study, 8 (6.4%) were considered to have a causal relationship to VONVENDI.2
These are not all the possible side effects with VONVENDI. You can ask your healthcare provider for information that is written for healthcare professionals. Tell your healthcare provider about any side effects that bother you or do not go away.
In the completed prophylaxis clinical study, 22 adult patients aged 18 years and older received prophylactic treatment with VONVENDI. The adverse drug reactions reported in this clinical trial are listed below.1
18.2% of participants (4 out of 22) experienced:
13.6% of participants (3 out of 22) experienced:
9.1% of participants (2 out of 22) experienced:
4.5% of participants (1 out of 22) experienced:
*Increased liver enzyme level in blood
In adult patients with VWD, VONVENDI is approved to control bleeds as they occur.1Learn more
In adult patients with VWD, VONVENDI is approved to manage bleeds related to procedures.1Learn more
See Detailed Important Risk Information
What is VONVENDI?
VONVENDI is used in adults (age 18 years and older) diagnosed with von Willebrand disease to:
Who should not use VONVENDI?
You should not use VONVENDI if you: