VONVENDI® safety

What you need to know about VONVENDI side effects

Side effects that have been reported with VONVENDI include: nausea, vomiting, tingling or burning at infusion site, chest discomfort, dizziness, hot flashes, itching, high blood pressure, muscle twitching, unusual taste, blood clots, and increased heart rate. Tell your healthcare provider about any side effects that bother you or do not go away.1

Doctor talking to her VWD patient.

Safety evaluated in four prospective, multicenter trials1

Three studies were conducted in subjects with von Willebrand disease (VWD) and one was conducted in subjects with hemophilia A. The adverse reactions reported in the three VWD trials, with a total of 80 participants, are listed below.1

Side effects (most common to least common)

3.75% of participants (3 out of 80) experienced:

Man with blurry vision icon.Dizziness
Stomach icon.Nausea
Unsettled stomach icon.Vomiting

2.5% of participants (2 out of 80) experienced:

Itching hand icon.Itching
Man with vertigo icon.Vertigo

1.25% of participants (1 out of 80) experienced:

Chest icon.Chest discomfort
Vein icon.Deep vein thrombosis
(blood clots)
Three flushes icon.Hot flush
Irregular heart icon.Hypertension
Heart rate trace icon.Increased heart rate
Needle icon.Tingling or burning at infusion site
Shaking man icon.Tremor
Tongue icon.Unusual taste

Of the 125 total adverse events observed during the study, 8 (6.4%) were considered to have a causal relationship to VONVENDI.2

These are not all the possible side effects with VONVENDI. You can ask your healthcare provider for information that is written for healthcare professionals. Tell your healthcare provider about any side effects that bother you or do not go away.

Real VWD patient, Erica standing next to some flowers and smiling. VONVENDI® can be used for on-demand treatment.
On-demand efficacy

A clinical trial tested VONVENDI in adults for on-demand use.1

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Doctor talking about VONVENDI® for surgical use.
Surgical use efficacy

A clinical trial tested VONVENDI in adults
with VWD undergoing surgery.1

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References

  1. VONVENDI Prescribing Information
  2. Gill JC, Giancarlo C, Windyga J, et al. Hemostatic efficacy, safety, and pharmacokinetics of a recombinant von Willebrand factor in severe von Willebrand disease. Blood. 2015;126(17):2038-2045.
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