Dosing and infusion
Your guide to dosing VONVENDI®
Following proper dosing and infusion guidelines is critical in safely and effectively administering VONVENDI.
Infusing VONVENDI
In order to help you control and manage bleeding episodes, VONVENDI is infused into your bloodstream. You can work with your healthcare provider to create a dosing and infusion plan that works best for you. This will include how and when to infuse VONVENDI, how much VONVENDI you should infuse, whether you might need additional recombinant FVIII (rFVIII), and any support you may need with mixing and administering.
Should I self-infuse?
Talk to your healthcare provider to see if self-infusion may be right for you. With self-infusion, you can administer VONVENDI on your own when a bleed occurs.
Where can I infuse?
You may infuse VONVENDI at a variety of locations, including a hemophilia treatment center, your healthcare provider's office, and your home.
Leslie’s Story
Diagnosed with VWD in 2003
"I try not to let my blood disorder get me down. As I tell my son, life is what you make of it. My adventure is not done; my story is not finished."
Erica’s Story
Diagnosed with VWD in 1981
"The doctor came back with a diagnosis: VWD type 2B. It was something I had never heard of before… but something that would change my life forever."
Nicole's Story
Diagnosed with VWD in 2009
"I was experiencing nosebleeds that lasted 15 minutes or more almost every day. My new doctor told me I needed to manage my bleeds, and discussed beginning a treatment called VONVENDI."
What to know before you infuse
Finding the right dose
Your healthcare provider will determine the amount of VONVENDI that is recommended for you depending on your weight, your type of VWD, and the severity of the bleeding event you're experiencing.
Additional factor VIII (FVIII)
Because your own von Willebrand factor (VWF) may not be able to protect the FVIII in your blood, your own levels of FVIII may be too low to help form a blood clot. Your healthcare provider will determine if you should use additional recombinant FVIII (rFVIII) along with your first dose of VONVENDI.
rFVIII for subsequent doses of VONVENDI
If you need more than one dose of VONVENDI for a bleeding event, your healthcare provider will determine if you need additional rFVIII. Always follow your healthcare provider's specific instructions about how to use VONVENDI with or without rFVIII. If you continue to bleed without noticeable improvement, contact your healthcare provider.
VONVENDI comes in two strengths
The actual strength will be printed on the vial label and on the box. Always check the actual dosage strength printed on the label to make sure you are using the strength prescribed by your healthcare provider.
Special dosing situations
Dosing can depend on the bleed
To treat a bleed, you may require more than one infusion of VONVENDI with or without rFVIII.
Dosing for surgery
If you're planning to have surgery, talk to your healthcare provider for guidance on dosing and administering VONVENDI with or without rFVIII.
Proper storage of VONVENDI
Store VONVENDI at refrigerated temperature 2°C to 8°C (36°F to 46°F) or room temperature not to exceed 30°C (86°F). Do not freeze. Store VONVENDI in the original box and protect it from extreme exposure to light. Do not use beyond the expiration date printed on the VONVENDI vial label or carton.
Additional infusion information
Always follow the specific instructions given by your healthcare provider. The steps listed on this page are general guidelines for using VONVENDI. If you are unsure of the procedures, please call your healthcare provider before using.
Call your healthcare provider right away if bleeding is not controlled after using VONVENDI.
Confirm your dosage. Your healthcare provider will prescribe the VONVENDI dose that you should take. If this is your first infusion to control a new bleeding episode, and if rFVIII is needed, be sure you also have the correct dose of rFVIII as instructed by your physician.
Occasional blood tests may be ordered by your healthcare provider.
Talk to your healthcare provider before traveling. Plan to bring enough VONVENDI for your treatment during this time.
Dispose of all materials in an appropriate container, including any leftover reconstituted VONVENDI product.
Try for free
You may be eligible to try VONVENDI for free with our FREEDOM OF CHOICE™ program.
