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Flip the connected syringe and VONVENDI product vial so the vial is on top (Figure J). Be sure to keep syringe plunger pressed in.
Slowly pull back the plunger to draw VONVENDI into the syringe (Figure K). Do not push and pull solution back and forth between syringe and vial. Doing so may harm the integrity of the product.
When ready to infuse, disconnect the syringe by turning it counterclockwise. Inspect syringe visually for particulate matter; the solution should be clear and colorless. If flakes or particles are seen, do not use the solution and notify your healthcare provider.
The contents of up to two vials may be drawn into a single syringe. When pushing air into a second vial of VONVENDI to be pooled into a syringe, position the vial and connected syringe so that the vial is on top. If you are using more than one vial, leave syringe attached to the vial or cover syringe tip with a suitable sterile cap until ready to infuse to reduce risk of contamination.
- For specific steps for pooling VONVENDI, please click here to see the Instructions For Use within the full Prescribing Information.
Make sure all syringes are ready before continuing with administration. See step 7 for administration instructions. You should administer immediately or within 3 hours, keeping it at room temperature (no warmer than 25°C/77°F). Do not refrigerate. Discard any unused reconstituted product after 3 hours.
If you need to infuse recombinant factor VIII (rFVIII), reconstitute it as instructed in the package insert for that product now. Make sure all syringes are ready before continuing with administration.