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nested-fragment, Accordion Nested Fragment

VONVENDI should be administered before any needed recombinant factor VIII (rFVIII)

Hold the syringe containing VONVENDI so the vial is on top. Turn the vial counterclockwise to disconnect it (Figure L). Do not touch the exposed connector.

Hands disconnecting the vial from the syringe.

Using a butterfly infusion set, attach the infusion needle to the syringe of VONVENDI. Point the needle up and remove any air bubbles by gently tapping the syringe with your finger and slowly and carefully pushing air out of the syringe and needle.

Apply a tourniquet and prepare the injection site by wiping your skin well with a sterile alcohol swab (or other suitable sterile solution).

Insert the needle into your vein, secure the needle in place, and remove the tourniquet. Slowly push the syringe plunger to administer VONVENDI (Figure M). Do not infuse any faster than 4 mL per minute. If your heart rate increases, you must stop administration and call your healthcare provider immediately for further instruction.

Hands administering VONVENDI® in the vein. Do not touch connector.

After you have administered all the VONVENDI, disconnect the syringe. If your dose requires multiple syringes, attach and administer them one at a time. Do not remove the butterfly needle until you have infused all syringes. Do not touch the Luer port that connects to the syringe.

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Content-flex, Center, nested-fragment, contained XS, Compact, Accordion Nested Fragment

If you are also infusing rFVIII, be sure to administer your complete dose of VONVENDI first, and then, if needed, infuse rFVIII within 10 minutes. No saline flushing is required prior to infusing rFVIII.

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Primary, Center, rounded, contained XS, Compact