Indication: VONVENDI [von Willebrand factor (recombinant)] is used in adults (age 18 years and older) diagnosed with von Willebrand disease to: treat and control bleeding episodes and prevent excessive bleeding during and after surgery


On-demand dosing based upon your needs

Your healthcare provider will determine dosing recommended

How much factor

Your healthcare provider will determine the amount of VONVENDI® [von Willebrand factor (Recombinant)] that is recommended for you depending on your weight, your type of VWD, and the severity of bleeding event you’re experiencing.4

Your healthcare provider will provide instructions for your first dose

Your first dose

Because your own von Willebrand factor (VWF) may not be able to protect the factor VIII (FVIII) in your blood, your own levels of FVIII may be too low to help form a blood clot. Your healthcare provider may prescribe your first dose of VONVENDI for each bleeding event with a recombinant FVIII (rFVIII).4

Your healthcare provider will determine your recommended dose

Additional doses

If you need more than one dose of VONVENDI for a bleeding event, your healthcare provider may determine you do not need any additional rFVIII.4

Always follow your healthcare provider’s specific instructions about how to use VONVENDI and/or rFVIII. If you continue to bleed without noticeable improvement, contact your healthcare provider.

If you're planning to have surgery, talk to your healthcare provider for guidance on dosing and administering VONVENDI.4

Selected Important Risk Information

You can have an allergic reaction to VONVENDI.

Call your healthcare provider right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting.

Depending on the bleed

In the clinical study, an average of 1 dose of VONVENDI treated mild-to-moderate bleeding episodes. People who experienced a major bleed required 2 or more doses. In one case, as many as 4 doses were needed to control bleeding.4

Who infuses VONVENDI

You may infuse VONVENDI at a hemophilia treatment center, your healthcare provider’s office, or in your home. You should be trained on how to do infusions by your healthcare provider or hemophilia treatment center.4

You will be trained on how to do infusions
HTC Locator: Find specialists in your area

HTC locator

Find specialists in your area

Help me out
Stay updated: Sign up for information from Shire

Stay updated

Sign up for information from Shire

Sign me up!