VONVENDI® safety
What you need to know about VONVENDI side effects
Side effects that have been reported with VONVENDI include: headache, nausea, vomiting, tingling or burning at infusion site, chest discomfort, dizziness, hot flashes, itching, high blood pressure, muscle twitching, unusual taste, blood clots, and increased heart rate. Tell your healthcare provider about any side effects that bother you or do not go away.
VONVENDI's safety profile was established in 6 clinical trials
Side effects in adults and children
The adverse reactions listed below are from 6 clinical trials in 103 adults and 29 children with VWD. The participants received intravenous infusions of VONVENDI with or without rFVIII and were followed for up to 4.6 years.
n (%)
*One patient developed infusion-related reaction experiencing chest discomfort and increased heart rate.
- VONVENDI is the first and only recombinant VWF for children and adults with VWD. Recombinant products are manufactured without using human blood. This technology avoids the risk of spreading diseases through infected human blood.
- Across all studies and age groups, no study participants developed anaphylaxis or neutralizing antibodies.
- Although no study participants developed anaphylaxis or neutralizing antibodies across all studies, your doctor should continue to advise/monitor for inhibitor development and signs of anaphylaxis.
Want to learn more about dosing and infusing VONVENDI?
You can work with your healthcare provider to create a dosing and infusion plan that works best for you. This will include how and when to infuse VONVENDI, how much VONVENDI you should infuse, whether you might need additional recombinant FVIII (rFVIII), and any support you may need with mixing and administering.
Try for free
You may be eligible to try VONVENDI for free with our FREEDOM OF CHOICE™ program.
Get personalized support
Community Education Specialists can help answer your questions about VONVENDI.