VONVENDI is used in adults (age 18 years and older) diagnosed with von Willebrand disease to: 1) treat and control bleeding episodes; 2) prevent excessive bleeding during and after surgery

VONVENDI® [von Willebrand factor (Recombinant)]

The only VWD factor treatment that's manufactured without human blood or plasma.^2,3

Can be used with or without recombinant FVIII as directed.¹

Created specifically to
treat VWD

VONVENDI^® is used to treat bleeds in adults with von Willebrand disease (VWD), an inherited bleeding disorder that makes it difficult to form blood clots.¹ VONVENDI is the first and only recombinant treatment for VWD, meaning it's made without using human blood.^2,3 Recombinant products have virtually no risk of being exposed to disease that can be spread through contamination by infected human blood.²

VONVENDI is also the first and only recombinant treatment for VWD that's approved for three uses including:

Routine prophylaxis in appropriate adult patients with severe type 3 VWD¹
On-demand to manage active bleeds¹
Perioperative to help prevent bleeding episodes during or after surgery¹

Learn about VONVENDI

See Detailed Important Risk Information

What is VONVENDI?

VONVENDI is used in adults (age 18 years and older) diagnosed with von Willebrand disease to:

treat and control bleeding episodes
prevent excessive bleeding during and after surgery
reduce the number of bleeding episodes when used regularly (prophylaxis) in adults with severe Type 3 von Willebrand disease receiving on-demand therapy

Who should not use VONVENDI?

You should not use VONVENDI if you:

Are allergic to any ingredients in VONVENDI
Are allergic to mice or hamsters

VONVENDI^® [von Willebrand factor (Recombinant)] Important Information

What is VONVENDI?

VONVENDI is used in adults (age 18 years and older) diagnosed with von Willebrand disease to:

treat and control bleeding episodes
prevent excessive bleeding during and after surgery
reduce the number of bleeding episodes when used regularly (prophylaxis) in adults with severe Type 3 von Willebrand disease receiving on-demand therapy

Detailed Important Risk Information

Who should not use VONVENDI?

You should not use VONVENDI if you:

Are allergic to any ingredients in VONVENDI.
Are allergic to mice or hamsters.

Tell your healthcare provider if you are pregnant or breastfeeding because VONVENDI may not be right for you.

How should I use VONVENDI?

Your first dose of VONVENDI for each bleeding episode may be administered with a recombinant factor VIII as instructed by your healthcare provider.

Your healthcare provider will instruct you whether additional doses of VONVENDI with or without recombinant factor VIII are needed.

What should I tell my healthcare provider before I use VONVENDI?

You should tell your healthcare provider if you:

Have or have had any medical problems.
Take any medicines, including prescription and non-prescription medicines, such as over-the-counter medicines, supplements or herbal remedies.
Have any allergies, including allergies to mice or hamsters.
Are breastfeeding. It is not known if VONVENDI passes into your milk and if it can harm your baby.
Are pregnant or planning to become pregnant. It is not known if VONVENDI can harm your unborn baby.
Have been told that you have inhibitors to von Willebrand factor (because VONVENDI may not work for you).
Have been told that you have inhibitors to blood coagulation factor VIII.

What else should I know about VONVENDI and von Willebrand Disease?

Your body can form inhibitors to von Willebrand factor or factor VIII. An inhibitor is part of the body’s normal defense system. If you form inhibitors, it may stop VONVENDI or factor VIII from working properly. Consult with your healthcare provider to make sure you are carefully monitored with blood tests for the development of inhibitors to von Willebrand factor or factor VIII.

What are the possible side effects of VONVENDI?

You can have an allergic reaction to VONVENDI.

Call your healthcare provider right away and stop treatment if you get a rash or hives, itching, tightness of the throat, chest pain or tightness, difficulty breathing, lightheadedness, dizziness, nausea or fainting.

Side effects that have been reported with VONVENDI include: headache, nausea, vomiting, tingling or burning at infusion site, chest discomfort, dizziness, joint pain, joint injury, increased liver enzyme level in blood, hot flashes, itching, high blood pressure, muscle twitching, unusual taste, blood clots and increased heart rate.

Tell your healthcare provider about any side effects that bother you or do not go away.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Please see VONVENDI full Prescribing Information

What could your deciding factor be?

Find a treatment specifically created for von Willebrand disease (VWD) bleeding episodes¹

The only VWD factor treatment that's manufactured without human blood or plasma.^2,3

Can be used with or without recombinant FVIII as directed.¹

Created specifically to
treat VWD

Living with VWD

References

What could your deciding factor be?

Find a treatment specifically created for von Willebrand disease (VWD) bleeding episodes1

The only VWD factor treatment that's manufactured without human blood or plasma.2,3

Can be used with or without recombinant FVIII as directed.1

Created specifically to treat VWD

Living with VWD

References

Find a treatment specifically created for von Willebrand disease (VWD) bleeding episodes¹

The only VWD factor treatment that's manufactured without human blood or plasma.^2,3

Can be used with or without recombinant FVIII as directed.¹

Created specifically to
treat VWD